TITLE: BMP7 Induces Dormancy of Prostatic Tumor Stem Cell in Bone PRINCIPAL INVESTIGATOR:
نویسنده
چکیده
presentation 1. Aya Kobayashi, Hiroshi Okuda, Puspa R. Pandey, Misako Watabe, Sudha K. Pai, Shigeru Hirota, Fei Xing, Wen Liu, Bo Xia, Kounosuke Watabe Poster Presentation: “BMP7 regulates dormancy and recurrence of prostate cancer stem cell in bone” Joint MRS-AACR Conference: Metastasis and the Tumor Microenvironment, 2010, Philadelphia, PA 2. Aya Kobayashi, Hiroshi Okuda, Puspa Pandey, Misako Watabe, Sudha K. Pai, Fei Xing, Shigeru Hirota, Wen Liu, and Kounosuke Watabe Poster Presentation: “Dormancy and recurrence of prostate cancer stem cell are regulated by bone morphogenetic protein 7 in bone” Department of Defense (DOD) Prostate Cancer Research Program (PCRP) Innovative Minds in Prostate Cancer Today (IMPaCT) Conference, 2011, Orlando, FL
منابع مشابه
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
Metastatic disease is the major cause of cancer deaths, and recurrent tumors at distant organs are a critical issue. However, how metastatic tumor cells become dormant and how and why tumors recur in target organs are not well understood. In this study, we demonstrate that BMP7 (bone morphogenetic protein 7) secreted from bone stromal cells induces senescence in prostate cancer stem-like cells ...
متن کاملDiverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells.
We found that bone morphogenetic protein (BMP) 7, a member of the BMP family, was strikingly up-regulated during the development of primary prostatic adenocarcinoma in the conditional Pten deletion mouse model. To determine the relevance of this finding to human prostate cancer, we examined the expression of BMPs and BMP receptors (BMPR) as well as the responsiveness to recombinant human BMP7 i...
متن کاملThe role of hematopoietic stem cell niche in prostate cancer bone metastasis
Approximately 80% of prostate cancers exhibit some degree of bone metastasis. The role of the bone marrow and the hematopoietic stem cell (HSC) niche in attracting metastatic cells and maintaining dormancy of disseminated tumor cells (DTCs) is an increasingly important topic towards the development of novel prostate cancer therapies. This paper reviews aspects of the HSC niche that lead to pros...
متن کاملThe marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer
Dissemination of cancer stem cells (CSCs) serves as the basis of metastasis. Recently, we demonstrated that circulating prostate cancer targets the hematopoietic stem cell (HSCs) 'niche' in marrow during dissemination. Once in the niche, disseminated tumor cells (DTCs) may remain dormant for extended periods. As the major function of the HSC niche is to maintain stem cell functions, we hypothes...
متن کاملThe Journal of Experimental Medicine Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
The authors noted that a reference regarding the suppressive effect of BMP7 on EMT and bone metastasis in prostate cancer was inadvertently omitted. The authors have added the following publication to the references: a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am. The html and pdf versions of this articl...
متن کامل